The role of trehalose and its transporter in protection against reactive oxygen species

During menadione stress, trehalose was necessary intracellularly, but under H2O2, the sugar was required on the outside of the plasma membrane. The mechanism of protection involves minimizing the oxidative damage caused to both proteins and lipids, which would require the presence of trehalose on both sides of the lipid bilayer. (C) 2008 Elsevier B.V. All rights reserved.