期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
卷 1780, 期 3, 页码 325-346出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagen.2007.08.015
关键词
glycosyl epitope; glycosphingolipid; ganglio-series; globo-series; lacto-series; tumor-associated antigen; developmentally regulated antigen; contact inhibition; cell growth; cell motility; cell adhesion; signal transduction; carbohydrate-carbohydmte interaction; microdomain; glycosynapse; sphingosine-dependent kinase; protein kinase C delta; tetraspanin; growth factor receptor; integrin; epigenetic regulation; stem cell; niche; epithelial-mesenchymal transition (EMT)
资金
- NCI NIH HHS [R35 CA042505-16] Funding Source: Medline
Based on development of various methodologies for isolation and characterization of glycosphingolipids (GSLs), we have identified a number of GSLs with globo-series or lacto-series structure. Many of them are tumor-associated or developmentally regulated antigens. The major question arose, what are their functions in cells and tissues? Various approaches to answer this question were undertaken. While the method is different for each approach, we have continuously studied GSL or glycosyl epitope interaction with functional membrane components, which include tetraspanins, growth factor receptors, integrins, and signal transducer molecules. Often, GSLs were found to interact with other carbohydrates within a specific membrane microdomain termed glycosynapse, which mediates cell adhesion with concurrent signal transduction. Future trends in GSL and glycosyl epitope research are considered, including stem cell biology and epithelial-mesenchymal transition (EMT) process. (c) 2007 Elsevier B.V. All rights reserved.
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