期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1839, 期 12, 页码 1362-1372出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2014.02.007
关键词
DNA methylation; Histone lysine methylation; Epigenetics; CpG island; Embryonic development
资金
- Wellcome Trust
- Lister Institute of Preventive Medicine
- European Molecular Biology Organization (EMBO)
- Cancer Research UK
DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has become clear that the DNA and histone lysine methylation systems are highly interrelated and rely mechanistically on each other for normal chromatin function in vivo. Here we examine some of the functional links between these systems, with a particular focus on several recent discoveries suggesting how lysine methylation may help to target DNA methylation during development, and vice versa. In addition, the emerging role of non-methylated DNA found in CpG islands in defining histone lysine methylation profiles at gene regulatory elements will be discussed in the context of gene regulation. This article is part of a Special Issue entitled: Methylation: A Multifaceted Modification looking at transcription and beyond. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
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