期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1839, 期 11, 页码 1097-1109出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2014.08.012
关键词
Long non-coding RNAs; Cancer; Epigenetics; Transcriptional regulation; Posttranscriptional regulation; Cancer diagnosis and therapy
资金
- National Science Foundation of China [NSFC31100979, NSFC81170149, NSFC81101050]
Unraveling the gene expression networks governing cancer initiation and development is essential while remains largely uncompleted. With the innovations in RNA-seq technologies and computational biology, long noncoding RNAs (lncRNAs) are being identified and characterized at a rapid pace. Recent findings reveal that IncRNAs are implicated in serial steps of cancer development. These IncRNAs interact with DNA, RNA, protein molecules and/or their combinations, acting as an essential regulator in chromatin organization, and transcriptional and post-transcriptional regulation. Their misexpression confers the cancer cell capacities for tumor initiation, growth, and metastasis. The review here will emphasize their aberrant expression and function in cancer, and the roles in cancer diagnosis and therapy will be also discussed.(C) 2014 Published by Elsevier B.V.
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