期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1829, 期 1, 页码 84-97出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2012.08.008
关键词
Transcription elongation; RNA polymerase II; Histone modifying enzyme; Chromatin remodeling; Histone chaperone; Intragenic transcription
资金
- NIGMS NIH HHS [R01 GM047867] Funding Source: Medline
Eukaryotic genomes are packaged into chromatin, a highly organized structure consisting of DNA and histone proteins. All nuclear processes take place in the context of chromatin. Modifications of either DNA or histone proteins have fundamental effects on chromatin structure and function, and thus influence processes such as transcription, replication or recombination. In this review we highlight histone modifications specifically associated with gene transcription by RNA polymerase II and summarize their genomic distributions. Finally, we discuss how (mis-)regulation of these histone modifications perturbs chromatin organization over coding regions and results in the appearance of aberrant, intragenic transcription. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation. (C) 2012 Elsevier B.V. All rights reserved.
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