期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1829, 期 9, 页码 916-920出版社
ELSEVIER
DOI: 10.1016/j.bbagrm.2013.04.010
关键词
Wnt/beta-catenin signaling; Mitosis; Stem cells; Differentiation; Protein stability; Mediator
资金
- Swedish Research Council
- Swedish Cancer Society
- IngaBritt and Arne Lundberg Foundation
- Swedish Foundation for Strategic Research
- Assar Gabrielsson Foundation
Cyclin dependent kinase 8 (Cdk8) is a component of Mediator, an evolutionary conserved multiprotein complex that regulates RNA polymerase II-dependent transcription. Cdk8 has been implicated as a regulator of multiple steps in cell cycle progression. We here discuss recent advances in our understanding of Cdk8 function and a possible role for Mediator as a hub for integrating transcription regulation with cell cycle progression. (c) 2013 Elsevier B.V. All rights reserved.
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