期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1829, 期 8, 页码 817-823出版社
ELSEVIER
DOI: 10.1016/j.bbagrm.2013.03.006
关键词
RNA helicase; mRNA decay; mRNA degradation; mRNA translational silencing
资金
- NIGMS NIH HHS [T32 GM008056, R01 GM080465] Funding Source: Medline
Translational control is a vital aspect of gene expression. Message specific translational repressors have been known for decades. Recent evidence, however, suggests that a general machinery exists that dampens the translational capacity of the majority of mRNAs. This activity has been best ascribed to a conserved family of RNA helicases called the DHH1/RCKp54 family. The function of these helicases is to promote translational silencing. By transitioning mRNA into quiescence, DHH1/RCKp54 helicases promote either mRNA destruction or storage. In this review we describe the known roles of these helicases and propose a mechanistic model to explain their mode of action. This article is part of a Special Issue entitled: The Biology of RNA helicases - Modulation for life. (C) 2013 Elsevier B.V. All rights reserved.
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