期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1829, 期 11, 页码 1202-1206出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2013.09.003
关键词
Transcription; RNA polymerase II; O-GlcNAc; Nutrient sensor
资金
- Intramural Program/CCR/NCI/NIH
Post-translational modifications play important roles in transcriptional regulation. Among the less understood PTMs is O-GlcNAcylation. Nevertheless, O-GlcNAcylation in the nucleus is found on hundreds of transcription factors and coactivators and is often found in a mutually exclusive ying-yang relationship with phosphorylation. O-GlcNAcylation also links cellular metabolism directly to the proteome, serving as a conduit of metabolic information to the nucleus. This review serves as a brief introduction to O-GlcNAcylation, emphasizing its important thematic roles in transcriptional regulation, and highlights several recent and important additions to the literature that illustrate the connections between O-GlcNAc and transcription. Published by Elsevier B.V.
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