期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 123, 期 3, 页码 361-365出版社
WILEY
DOI: 10.1046/j.1365-2249.2001.01454.x
关键词
ageing; autoantibodies; animal models; baboons
类别
资金
- NCRR NIH HHS [R29 RR010755, RR10755] Funding Source: Medline
Autoantibody production increases with ageing. However, the pathological significance of this increase as well as the corresponding underlying mechanisms are poorly understood. To further our understanding of the role that ageing plays in the development of autoantibody responses, we used a novel nonhuman primate model consisting of healthy baboons of ages representing the entire lifespan of this animal species. Results from this study indicate that production of antinuclear antibodies, anticell extract antibodies and natural autoantibodies gradually and significantly increases from young age to old age without a corresponding increase in neither serum immunoglobulin concentration nor in levels of selected markers of immune dysregulation (sTNF-RI, sTNF-RII, IL-2 sR alpha and IFN-gamma). Therefore, in the baboon model, autoantibodies may be produced in absence of recognizable pathological conditions of the ageing immune system.
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