期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1819, 期 7, 页码 688-693出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2012.02.006
关键词
Promoter; Chromatin; Transcription; Gene regulation
资金
- Intramural NIH HHS [Z99 CA999999] Funding Source: Medline
The sequencing of the human genome led to many insights into gene organization and structure. One interesting observation was the high frequency of bidirectional promoters characterized by two protein encoding genes whose promoters are arranged in a divergent or head-to-head configuration with less than 2000 base pairs of intervening sequence. Computational estimates published by various groups indicate that nearly 10% of the coding gene promoters are arranged in such a manner and the extent of this bias is a unique feature of mammalian genomes. Moreover, as a class, head-to-head promoters appear to be enriched in specific categories of gene function. Here we review the structure, composition, genomic properties and functional classifications of genes controlled by bidirectional promoters and explore the biological implication of these features. This article is part of a Special Issue entitled: Chromatin in time and space. Published by Elsevier B.V.
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