期刊
DRUG AND ALCOHOL DEPENDENCE
卷 62, 期 1, 页码 49-56出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0376-8716(00)00159-9
关键词
brain imaging; hormonal effects; magnetic resonance imaging; cocaine dependence
资金
- NCRR NIH HHS [RR00125] Funding Source: Medline
- NIDA NIH HHS [DA00167, DA09250, DA04060] Funding Source: Medline
Preclinical and clinical studies have shown that cocaine increases plasma adrenocorticotropin hormone (ACTH) and cortisol. Chronic elevation of plasma cortisol exerts direct toxic effects upon hippocampal neurons and exacerbates hippocampal damage resulting from ischemia and seizures. The authors tested for evidence of hippocampal damage in patients with chronic cocaine dependence. Medial temporal lobe and total brain volumes were quantified using magnetic resonance imaging (MRI) in 27 patients with cocaine dependence and 16 healthy subjects. Basal and ovine corticotropin releasing hormone (oCRH) stimulated ACTH and cortisol levels were also examined in a subset of 8 healthy and 9 cocaine dependent subjects after 21 days of abstinence. No evidence for decreased hippocampal or total brain volume in cocaine dependence was observed. Similarly, basal and oCRH stimulated ACTH and cortisol levels in cocaine dependent patients did not differ from those in healthy subjects. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据