期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1799, 期 1-2, 页码 3-14出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2009.09.001
关键词
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资金
- NIH [R01-GM071760]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM071760] Funding Source: NIH RePORTER
Although the three families of mammalian HIVIG proteins (HMGA, HMGB and HMGN) participate in many of the same nuclear processes, each family plays its own unique role in modulating chromatin structure and regulating genomic function. This review focuses oil the similarities and differences in the mechanisms by which the different HMG families impact chromatin Structure and influence cellular phenotype. The biological implications of having three architectural transcription factor families with complementary, but partially overlapping, nuclear functions are discussed. (C) 2009 Elsevier B.V. All rights reserved.
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