期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1799, 期 3-4, 页码 217-222出版社
ELSEVIER
DOI: 10.1016/j.bbagrm.2009.08.004
关键词
Herpes simplex virus; HSV-1; Chromatin-modifying coactivator; Histone acetyltransferase; Chromatin remodeling enzyme; VP16; Histone; Nucleosome; Lytic infection; Latent infection
资金
- Van Andel Research Institute
- NIH [AI-064634]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI064634] Funding Source: NIH RePORTER
The human herpes simplex viruses HSV-1 and HSV-2 infect a significant portion of the human population. Both viruses can undergo lytic infection in epithelial cells and establish lifelong latency in neuronal cells. The large HSV-1 DNA genomes have long been considered to be devoid of histones both inside the virion particle and inside the cell during lytic infection, but to be packaged in repressive chromatin during latency. However, recent reports indicate that many histone and non-histone chromosomal proteins can associate with viral DNA during lytic infection and may influence important events during the HSV-1 lytic cycle. In this article, we summarize recent developments in this field and their implications. (C) 2009 Elsevier B.V. All rights reserved.
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