期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1799, 期 1-2, 页码 149-156出版社
ELSEVIER
DOI: 10.1016/j.bbagrm.2009.11.019
关键词
Cytokine; HMGB1; Inflammation; Immune response; Receptor
资金
- NIH NCRR [M01 RR018535]
- NIH NIGMS
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR018535] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM062508] Funding Source: NIH RePORTER
High mobility group box 1 (HMGB1). a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, is a necessary and Sufficient mediator of inflammation during sterile and infection-associated responses. Elevated levels of HMGB1 in serum and tissues occur during sterile tissue injury and during infection, and targeting HMGB1 with antibodies or specific antagonists is protective in established preclinical inflammatory disease models including lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury. Future advances in this field will stein from understanding the biological basis for the success of targeting HMGB1 to therapeutic improvement in the treatment of inflammation, infection and ischemia-reperfusion induced injury. (C) 2009 Published by Elsevier B.V.
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