期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1779, 期 12, 页码 850-859出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2008.08.010
关键词
RNA polymerase I; Transcription; Ubiquitin proteasome system
资金
- Deutsche Forschungsgemeinschaft
- Fonds der Chemischen Industrie
- Janos Bolyai postdoctoral fellowship
Significant amount of data have accumulated in the last several years pointing to the essential role of the ubiquitin proteasome system in the regulation of RNA polymerase II transcription; however, its involvement in RNA polymerase I transcription has remained largely unexplored. In this study, we demonstrate that proteasome activity is required for pre-rRNA synthesis. We can detect the association of proteasomal ATPases with both the rDNA promoter and coding region. Additionally, we show that the RNA polymerase I associated transcription factor, TIF-IA interacts with proteasomal ATPases, representing a potential link via which proteasomes and/or proteasome related complexes are recruited to rRNA genes. In summary, our findings suggest that the ubiquitin proteasome system is directly involved in RNA polymerase I transcription in analogy to the RNA polymerase II system. (C) 2008 Elsevier B.V. All rights reserved.
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