期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1779, 期 9, 页码 538-549出版社
ELSEVIER
DOI: 10.1016/j.bbagrm.2008.06.012
关键词
mRNA surveillance; Nonsense-mediated mRNA decay; Premature translation; Termination; mRNA turnover; mRNA quality control
资金
- CONACYT, Mexico
- Swiss National Science Foundation
- Novartis Foundation for Biomedical Research
- Helmut Horten Foundation
Among the different cellular surveillance mechanisms in charge to prevent production of faulty gene products, nonsense-mediated mRNA decay (NMD) represents a translation-dependent posttranscriptional process that selectively recognizes and degrades mRNAs whose open reading frame (ORF) is truncated by a premature translation termination codon (PTC, also called nonsense codon). In doing so, NMD protects the cell from accumulating C-terminally truncated proteins with potentially deleterious functions. Transcriptome profiling of NMD-deficient yeast, Drosophila, and human cells revealed that 3-10% of all mRNA levels are regulated (directly or indirectly) by NMD, indicating an important role of NMD in gene regulation that extends beyond quality control [J. Rehwinkel, J. Raes, E. Izaurralde, Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors, Trends Biochem. Sci. 31 (2006) 639-646. [1]]. In this review, we focus on recent results from different model organisms that indicate an evolutionarily conserved mechanism for PTC identification. (C) 2008 Elsevier B.V. All rights reserved.
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