期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1779, 期 8, 页码 438-452出版社
ELSEVIER
DOI: 10.1016/j.bbagrm.2008.01.003
关键词
alternative splicing; Ca(++)signal; pre-mRNA element; splicing factor; gene expression; neuron; brain; ion channel; neurodegenerative disease; protein diversity; fine-tuning
资金
- Canadian Institutes of Health Research (CIHR) [68919]
- National Cancer Institute of Canada (NCIC) [016355]
- Manitoba Health Research Council
- Canada Foundation for Innovation (CFI)
Alternative pre-mRNA splicing is a common way of gene expression regulation in metazoans. The selective use of specific exons can be modulated in response to various manipulations that alter Ca++ signals, particularly in neurons. A number of splicing factors have also been found to be controlled by Ca++ signals. Moreover, pre-mRNA elements have been identified that are essential and sufficient to mediate Ca++-regulated splicing, providing model systems for dissecting the involved molecular components. In neurons, this regulation likely contributes to the fine-tuning of neuronal properties. Crown Copyright (c) 2008 Published by Elsevier B.V. All rights reserved.
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