期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1838, 期 2, 页码 557-568出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2013.07.009
关键词
Cytoskeleton; Actin polymerization; Calcium; TCR; Signaling; Lymphocyte
资金
- Israel Science Foundation [1659/08, 971/08, 1503/08, 491/10]
- Ministry of Health [3-4114, 3-6540]
- Israel Cancer Association through the Estate of the late Alexander Smidoda
- Taubenblatt Family Foundation for a Bio-medicine grant for excellence
- Ministry of Science [3-4114, 3-6540]
During T cell activation, the engagement of a T cell with an antigen-presenting cell (APC) results in rapid cytoskeletal rearrangements and a dramatic increase of intracellular calcium (Ca2+) concentration, downstream to T cell antigen receptor (TCR) ligation. These events facilitate the organization of an immunological synapse (IS), which supports the redistribution of receptors, signaling molecules and organelles towards the T cell-APC interface to induce downstream signaling events, ultimately supporting T cell effector functions. Thus, Ca2+ signaling and cytoskeleton rearrangements are essential for T cell activation and T cell-dependent immune response. Rapid release of Ca2+ from intracellular stores, e.g. the endoplasmic reticulum (ER), triggers the opening of Ca2+ release-activated Ca2+ (CRAC) channels, residing in the plasma membrane. These channels facilitate a sustained influx of extracellular Ca2+ across the plasma membrane in a process termed store-operated Ca2+ entry (SOCE). Because CRAC channels are themselves inhibited by Ca2+ ions, additional factors are suggested to enable the sustained Ca2+ influx required for T cell function. Among these factors, we focus here on the contribution of the actin and microtubule cytoskeleton. The TCR-mediated increase in intracellular Ca2+ evokes a rapid cytoskeleton-dependent polarization, which involves actin cytoskeleton rearrangements and microtubule-organizing center (MTOC) reorientation. Here, we review the molecular mechanisms of Ca2+ flux and cytoskeletal rearrangements, and further describe the way by which the cytoskeletal networks feedback to Ca2+ signaling by controlling the spatial and temporal distribution of Ca2+ sources and sinks, modulating TCR-dependent Ca2+ signals, which are required for an appropriate T cell response. This article is part of a Special Issue entitled: Reciprocal influences between cell cytoskeleton and membrane channels, receptors and transporters. Guest Editor: Jean Claude Herve. (C) 2013 Elsevier B.V. All rights reserved.
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