期刊
MOLECULAR CELL
卷 7, 期 3, 页码 497-508出版社
CELL PRESS
DOI: 10.1016/S1097-2765(01)00197-6
关键词
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资金
- NICHD NIH HHS [HD33760] Funding Source: Medline
The coordinated division of distinctive types of stem cells within an organ is crucial for organogenesis and homeostasis. Here we show genetic interactions among fs(1)Yb (Yb), piwi, and hedgehog (hh) that regulate the division of both germline stem cells (GSCs) and somatic stem cells (SSCs), the two constituent stem cell populations of the Drosophila ovary. Yb is required for both GSC and SSC divisions; loss of Yb function eliminates GSCs and reduces SSC division, while Yb overexpression increases GSC number and causes SSC overproliferation. We also show that Yb acts via the piwi- and hh-mediated signaling pathways that emanate from the same signaling cells to control GSC and SSC division, respectively, hh signaling also has a minor effect in GSC division.
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