期刊
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
卷 6, 期 3, 页码 275-284出版社
SPRINGER-VERLAG
DOI: 10.1007/s007750000198
关键词
lipoxygenase; model compounds; nonheme iron; peroxo complexes
资金
- NIGMS NIH HHS [GM-33162] Funding Source: Medline
The air-stable complex [Fe(6-Me-3-TPA) (O2CAr)](+) [1; 6-Me-3-TPA= tris(6-me thyl-2-pyridylmethyl)amine] has been synthesized as a model for the iron(II) site of lipoxygenase. This iron(II) complex reacts with 0.5 equiv ROOH to form a yellow species. which has been formulated as [Fe-III(OH)(6-Me-3-TPA)(O2CAr)](+) (2) by electrospray mass spectrometry. Addition of more ROOH converts 2 into a purple species, which is characterized by electrospray ionization mass spectrometry and resonance Raman spectroscopy as [Fe-III(OOR)(6-Me-3-TPA)(O2CAr)](+). The purple species is metastable and decomposes via Fe-O bond homolysis to regenerate the starting iron(II) complex. These metal-centered transformations parallel the changes observed for lipoxygenase in its reaction with its product hydroperoxide.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据