期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1838, 期 10, 页码 2412-2419出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2014.06.006
关键词
Vesicles; Fluctuations; Neutron spectroscopy
资金
- HZB
We report a combined dynamic light scattering (DLS) and neutron spin-echo (NSE) study on the local bilayer undulation dynamics of phospholipid vesicles composed of 1,2-dimyristoyl-glycero-3-phosphatidylcholine (DMPC) under the influence of temperature and the additives cholesterol and trehalose. The additives affect vesicle size and self-diffusion. Mechanical properties of the membrane and corresponding bilayer undulations are tuned by changing lipid headgroup or acyl chain properties through temperature or composition. On the local length scale, changes at the lipid headgroup influence the bilayer bending rigidity is less than changes at the lipid acyl chain: We observe a bilayer softening around the main phase transition temperature T. of the single lipid system, and stiffening when more cholesterol is added, in concordance with literature. Surprisingly, no effect on the mechanical properties of the vesicles is observed upon the addition of trehalose. (C) 2014 Elsevier B.V. All rights reserved.
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