4.8 Article

Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi

期刊

EMBO JOURNAL
卷 20, 期 5, 页码 971-978

出版社

WILEY
DOI: 10.1093/emboj/20.5.971

关键词

Lyme disease; OspC; 3D structure; X-ray diffraction

资金

  1. NIAID NIH HHS [AI37256] Funding Source: Medline
  2. NINDS NIH HHS [P01-NS34092-01A2] Funding Source: Medline

向作者/读者索取更多资源

Outer surface protein C (OspC) is a major antigen on the surface of the Lyme disease spirochete, Borrelia burgdorferi, when it is being transmitted to humans. Crystal structures of OspC have been determined for strains HB19 and B31 to 1.8 and 2.5 Angstrom resolution, respectively. The three-dimensional structure is predominantly helical. This is in contrast to the structure of OspA, a major surface protein mainly present when spirochetes are residing in the midgut of unfed ticks, which is mostly P-sheet. The surface of OspC that would project away from the spirochete's membrane has a region of strong negative electrostatic potential which may be involved in binding to positively charged host ligands. This feature is present only on OspCs from strains known to cause invasive human disease.

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