期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1838, 期 11, 页码 2910-2918出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2014.07.028
关键词
Antimicrobial peptide; HAL-2; NMR spectroscopy; Aggregation; Amyloid formation
资金
- Natural Science Foundation of China [21372222, 21103199]
- Hefei Center for Physical Science and Technology
Lipopolysaccharide (LPS), the important component of the outer membrane of Gram-negative bacteria, contributes to the integrity of the outer membrane and protects the cell against bactericidal agents, including antimicrobial peptides. However, the mechanisms of interaction between antimicrobial peptides and LPS are not clearly understood. Halictines-2 (HAL-2), one of the novel antimicrobial peptides, was isolated from the venom of the eusocial bee Halictus sexcinctus. HAL-2 has exhibited potent antimicrobial activity against Gram-positive and Gram-negative bacteria and even against cancer cells. Here, we studied the interactions between HAL-2 and LPS to elucidate the antibacterial mechanism of HAL-2 in vitro. Our results show that HAL-2 adopts a significant degree of beta-strand structure in the presence of LPS. LPS is capable of inducing HAL-2 amyloid formation, which may play a vital role in its antimicrobial activity. (C) 2014 Elsevier B.V. All rights reserved.
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