期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 46, 期 1-3, 页码 125-148出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-409X(00)00136-8
关键词
controlled release; controlled drug delivery; self-regulated drug delivery; externally regulated drug delivery; pulsatile drug delivery; environmentally sensitive polymer; insulin delivery
This paper discusses the state of the art in a relatively new approach in the field of controlled drug delivery-responsive polymeric drug delivery systems. Such systems are capable of adjusting drug release rates in response to a physiological need. The fundamental principles of externally and self-regulated delivery systems are examined. Special attention is paid to specific clinical settings such as diabetes, presenting the advantages and disadvantages of different approaches. (C) 2001 Elsevier Science B.V. All rights reserved.
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