期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1828, 期 1, 页码 134-146出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2012.05.026
关键词
Electrical synapse; Connexin 36; Synaptic plasticity; Electrical coupling; Auditory; Synchronization
资金
- National Institutes of Health [DC03186, DC011099, R21NS055726, NS0552827]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS052827, R21NS055726] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC011099, R01DC003186, R29DC003186, R56DC003186] Funding Source: NIH RePORTER
The term synapse applies to cellular specializations that articulate the processing of information within neural circuits by providing a mechanism for the transfer of information between two different neurons. There are two main modalities of synaptic transmission: chemical and electrical. While most efforts have been dedicated to the understanding of the properties and modifiability of chemical transmission, less is still known regarding the plastic properties of electrical synapses, whose structural correlate is the gap junction. A wealth of data indicates that, rather than passive intercellular channels, electrical synapses are more dynamic and modifiable than was generally perceived. This article will discuss the factors determining the strength of electrical transmission and review current evidence demonstrating its dynamic properties. Like their chemical counterparts, electrical synapses can also be plastic and modifiable. This article is part of a Special Issue entitled: The Communicating junctions, roles and dysfunctions. (C) 2012 Elsevier B.V. All rights reserved.
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