期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1818, 期 11, 页码 2477-2485出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2012.05.018
关键词
Fluorescence spectroscopy; Fluorescence correlation spectroscopy; Plasma membrane organization; Microdomain; Membrane fluidity
资金
- French National Research Agency [ANR-JC07-190015/ANR-07-JCJC-0154]
- Ligue Contre le Cancer (Comite de l'Aube)
- Conseil General de l'Aube
Diffusion time distribution analysis has been employed to highlight the microfluidity fingerprint of plasma membrane of living cells. Diffusion time measurements were obtained through fluorescence correlation spectroscopy performed at the single cell level, over various eukaryotic cell lines (MCF7, LR73, KB3.1, MESSA and MDCKII). The nonsymmetric profile of the diffusion time distributions established experimentally, is discussed according to Monte Carlo simulations, which reproduce the diffusion of the fluorescent probe in heterogeneous membrane. (C) 2012 Elsevier B.V. All rights reserved.
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