期刊
MOLECULAR CELL
卷 7, 期 3, 页码 475-485出版社
CELL PRESS
DOI: 10.1016/S1097-2765(01)00195-2
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资金
- NICHD NIH HHS [HD37487] Funding Source: Medline
- NIGMS NIH HHS [GM49869] Funding Source: Medline
The endoderm and much of the mesoderm arise from the EMS cell in the four-cell C. elegans embryo. We report that the MED-1 and -2 GATA factors specify the entire fate of EMS, which otherwise produces two C-like mesectodermal progenitors. The meds are direct-targets of the maternal SKN-1 transcription factor; however, their forced expression can direct SKN-1-independent reprogramming of non-EMS cells into mesendodermal progenitors. We find that SGG-1/GSK-3 beta kinase acts both as a Wnt-dependent activator of endoderm in EMS and an apparently Wnt-independent repressor of the meds in the C lineage, indicating a dual role for this kinase in mesendoderm development. Our results suggest that a broad tissue territory, mesendoderm, in vertebrates has been confined to a single cell in nematodes through a common gene regulatory network.
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