期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1808, 期 11, 页码 2761-2771出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2011.07.022
关键词
Area per lipid; Bilayer structure; Fluid phase; Neutron scattering; X-ray scattering; Phosphatidylcholine
资金
- Office of Biological and Environmental Research at Oak Ridge National Laboratory's (ORNL) Center for Structural Molecular Biology (CSMB)
- UT-Battelle, LLC [DE-AC05-000R2275]
- National Science Foundation [DMR-0944772]
- Cornell High Energy Synchrotron Source (CHESS)
- National Institutes of Health/National Institute of General Medical Sciences under National Science Foundation [DMR-0225180]
- ORNL's Laboratory Directed Research and Development (LORD)
- Development (LORD) program
The structural parameters of fluid phase bilayers composed of phosphatidylcholines with fully saturated, mixed, and branched fatty acid chains, at several temperatures, have been determined by simultaneously analyzing small-angle neutron and X-ray scattering data. Bilayer parameters, such as area per lipid and overall bilayer thickness have been obtained in conjunction with intrabilayer structural parameters (e.g. hydrocarbon region thickness). The results have allowed us to assess the effect of temperature and hydrocarbon chain composition on bilayer structure. For example, we found that for all lipids there is, not surprisingly, an increase in fatty acid chain trans-gauche isomerization with increasing temperature. Moreover, this increase in trans-gauche isomerization scales with fatty acid chain length in mixed chain lipids. However, in the case of lipids with saturated fatty acid chains, trans-gauche isomerization is increasingly tempered by attractive chain-chain van der Waals interactions with increasing chain length. Finally, our results confirm a strong dependence of lipid chain dynamics as a function of double bond position along fatty acid chains. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
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