期刊
JAPANESE JOURNAL OF CANCER RESEARCH
卷 92, 期 3, 页码 352-360出版社
JAPANESE CANCER ASSOC
DOI: 10.1111/j.1349-7006.2001.tb01102.x
关键词
CDK2; cyclin A; cyclin E; oral cancer; prognosis
类别
资金
- NIDCR NIH HHS [P01 DE12467, R01 DE08680] Funding Source: Medline
Cyclins and cyclin-dependent kinases (CDKs) play key roles in cell cycle regulation, a process of which dysregulation can lead to uncontrolled cell grow th and hence to cancer. We have already reported the alteration of CDK4 and cyclin D1 expression in oral cancer. In this study, we examined by immunohistochemistry the expression of CDK2, and cyclins A and E in 20 normal oral mucosa, 42 dysplastic epithelia, and 103 oral squamous cell carcinomas (SCCs). The expressions of CDK2, and cyclins A and E were not detected in the normal epithelium and significantly altered from epithelial dysplasia to SCC, While there were no significant correlations between the expression of cyclins A, E and the patients' survival, CDK2 expression was significantly correlated with lymph node involvement (P=0.025), tumor differentiation (P=0.032), mode of tumor invasion (P=0.017), and shorter survival period (P=0.0173), These results suggest that the elevated expression of CDK2 is a critical factor in oral cancer progression and can be used as a negative predictive marker of the patients' prognosis.
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