期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 103, 期 8, 页码 1632-1640出版社
WILEY
DOI: 10.1002/jbm.b.33341
关键词
biodegradable metal; zinc alloy; extrusion; mechanical properties; cytotoxicity
资金
- NIGMS NIH HHS [R01 GM113052, R01 GM086788] Funding Source: Medline
Zinc-Magnesium (Zn-Mg) alloy as a novel biodegradable metal holds great potential in biodegradable implant applications as it is more corrosion resistant than Magnesium (Mg). However, the mechanical properties, biodegradation uniformity, and cytotoxicity of Zn-Mg alloy remained as concerns. In this study, hot extrusion process was applied to Zn-1 wt % Mg (Zn-1Mg) to refine its microstructure. Effects of hot extrusion on biodegradation behavior and mechanical properties of Zn-1Mg were investigated in comparison with Mg rare earth element alloy WE43. Metallurgical analysis revealed significant grain size reduction, and immersion test found that corrosion rates of WE43 and Zn-1Mg were reduced by 35% and 57%, respectively after extrusion. Moreover, hot extrusion resulted in a much more uniform biodegradation in extruded Zn-1Mg alloy and WE43. In vitro cytotoxicity test results indicated that Zn-1Mg alloy was biocompatible. Therefore, hot extruded Zn-1Mg with homogenous microstructure, uniform as well as slow degradation, improved mechanical properties, and good biocompatibility was believed to be an excellent candidate material for load-bearing biodegradable implant application. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1632-1640, 2015.
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