期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 13, 期 3, 页码 467-474出版社
JOHN WILEY & SONS INC
DOI: 10.1002/jmri.1068
关键词
lung; lung magnetic resonance imaging; lung biomechanics; tagged magnetization; strain mapping
资金
- NHLBI NIH HHS [HL57437] Funding Source: Medline
In clinical practice, the assessment of lung mechanics is limited to a global physiological evaluation, which measures, in the aggregate, the contributions of the pulmonary parenchyma, pleura, and chest wall. In this study, we used an MR imaging methodology which applies two-dimensional bands of inverted magnetization directly onto the pulmonary parenchyma, thus allowing for the quantification of local pulmonary tissue deformation, or strain, throughout inhalation. Our results showed that the magnitude of strain was maximal at the base and apex of the lung, but was curtailed at the hilum, the anatomical site of the poorly mobile bronchial and vascular insertions. Inplane shear strain mapping showed mostly positive shear strain, predominant at the apex throughout inhalation, and increasing with expanding lung volume. Anisotropy mapping showed that superior-inferior axial strain was greater than medial-lateral axial strain at the apex and base, while the opposite was true for the middle lung field. This study demonstrates that localized pulmonary deformation can be measured in vivo with tagging AM, and quantified by applying finite strain definitions from continuum mechanics. (C) 2001 Wiley-Liss, Inc.
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