期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1788, 期 1, 页码 97-121出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2008.08.022
关键词
Sterol; Lipid bilayer; Unsaturated lipid; Sphingolipid; Lipid raft; Molecular dynamics simulation
资金
- Academy of Finland
- Jenny and Antti Wihuri Foundation
- SharcNet
- Emil Aaltonen Foundation
- Polish Committee for Scientific Research [6P04A05715, 6P04A03121]
- Natural Sciences and Engineering Research Council of Canada (NSERC)
Without any exaggeration, cholesterol is one of the most important lipid species in eukaryotic cells. Its effects on cellular membranes and functions range from purely mechanistic to complex metabolic ones, be;ides which it is also a precursor of the sex hormones (steroids) and several vitamins. In this review, we discuss the biophysical effects of cholesterol on the lipid bilayer, in particular the ordering and condensing effects, concentrating on the molecular level or inter-atomic interactions perspective, starting from two-component systems and proceeding to many-component ones e.g., modeling lipid rafts. Particular attention is paid to the roles of the methyl groups in the cholesterol ring system, and their possible biological function. Although our main research methodology is computer modeling, in this review we make extensive comparisons between experiments and different modeling approaches. (C) 2008 Elsevier B.V. All rights reserved.
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