期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1788, 期 8, 页码 1687-1692出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2008.09.013
关键词
Antimicrobial peptide; Cell selectivity; Electrostatic interaction; Hydrophobicity; D-amino acid; Peptpoid
资金
- JSPS [20659005]
- Grants-in-Aid for Scientific Research [20659005] Funding Source: KAKEN
Antimicrobial peptides (AMPs) are promising novel antibiotics, because they exhibit broad antimicrobial spectra and do not easily induce resistance. For clinical applications, it is important to develop potent AMPs with less toxicity against host cells. This review article summarizes the molecular basis for the cell selectivity (bacteria versus host cells) of AMPs and various attempts to control it, including the optimization of physicochemical parameters of peptides, the introduction Of D-, fluorinated, and unusual amino acids into peptides, the constraining of peptide conformations, and the modification of peptides by polymers. Pros and cons of these approaches are discussed. (C) 2008 Elsevier BY. All rights reserved.
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