期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 105, 期 1, 页码 81-90出版社
WILEY
DOI: 10.1002/jbm.b.33394
关键词
curcumin; chitosan; pluronic; nanoparticles; wound regeneration
资金
- Ministry of Science and Technology (MOST) [103-2320-B-039-002-MY3]
- China Medical University [CMU-101-S-22, CMU102-S-23]
The hydrophobic polyphenol curcumin has anti-inflammatory, antimicrobial, and wound-healing properties that warrant its pharmacological consideration. We report a curcumin nanoparticle with a tripolymeric composite that can be used as a delivery device for wound healing. The present composite nanoparticles were prepared with three biocompatible polymers of chitosan, poly-gamma-glutamic acid, and pluronic using a simple ionic gelation technology. Pluronic was used to enhance the solubility of curcumin in chitosan/poly-gamma-glutamic acid nanoparticles, leading to the incorporation of chitosan/poly-gamma-glutamic acid/pluronic/curcumin nanoparticles into chitosan membranes, and reduced inflammation and bacterial infection during wound regeneration. Nanoparticles were of 193.1 +/- 8.9 nm and had a zeta potential of 20.6 +/- 2.4 mV. Moreover, in vitro analyses indicated controlled curcumin release in a simulated skin tissue model. Subsequent in vivo studies show that chitosan wound dressing containing chitosan/poly-gamma-glutamic acid/pluronic/curcumin nanoparticles promoted neocollagen regeneration and tissue reconstruction. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 81-90, 2017.
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