期刊
JOURNAL OF INFECTIOUS DISEASES
卷 183, 期 5, 页码 814-818出版社
UNIV CHICAGO PRESS
DOI: 10.1086/318828
关键词
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The effect of CC-chemokine receptor 5 (CCR5) promoter polymorphisms on the natural history of human immunodeficiency virus (HIV) disease was studied in 73 HIV-1-infected children. The CCR559338-59537 promoter haplotype, CCR5-59029A/G polymorphism, and CCR5 Delta 32 and CCR2-64I alterations were investigated. After exclusion of carriers of CCR5D32 or CCR2-64I, Kaplan-Meier analysis disclosed that children with the P1/P1(59353C,59356C,59402A) genotype progressed faster to disease than did children with other haplotypes (P = .016). When CCR2-64I carriers were included, this effect had borderline significance (P = .065) and was lost when CCR5D32 carriers were also considered (P = .387). The P1/P1 effect was strongest early after infection, when progression to disease was mainly associated with CCR5 coreceptor-using viruses. These results indicate that the P1/P1 genotype is predictive of rapid progression in HIV-1-infected children lacking CCR5D32 or CCR5-64I alleles. The observation of a linkage disequilibrium between P1 and 59029A might explain the previously reported association between 59029A homozygosity and rapid disease progression.
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