期刊
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
卷 438, 期 3, 页码 306-311出版社
SPRINGER-VERLAG
DOI: 10.1007/s004280000314
关键词
Chlamydia trachomatis; salpingitis; immunecomplex glomerulopathy; interleukin-6; levofloxacin
类别
A 24-year-old woman presented with renal insufficiency, macrohematuria, and mild urinary protein. Polyclonal hypergamma-globulinemia, thrombocytosis, increased concentration of serum, and urinary interleukin (IL)-6 all indicated persistent immune activation caused by a Chlamydia trachomatis infection of the fallopian tube. Gynecological treatment with levofloxacin was effective both for the renal symptoms and other immunological parameters. First and second renal biopsy specimens showed an immune-complex glomerulopathy with extensive interstitial infiltration of many types of inflammatory cells, including plasma cells. Thus, we conclude that chlamydial salpingitis must be considered as one causative disease factor for renal involvement by means of its persistent immune activation effects.
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