期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1778, 期 3, 页码 757-769出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2007.11.007
关键词
tight junction; septate junction; Na,K-ATPase; channel; transporter
资金
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK056216] Funding Source: NIH RePORTER
- NIDDK NIH HHS [R01 DK056216, DK56216] Funding Source: Medline
Tight junctions are unique organelles in epithelial cells. They are localized to the apico-lateral region and essential for the epithelial cell transport functions. The paracellular transport process that occurs via tight junctions is extensively studied and is intricately regulated by various extracellular and intracellular signals. Fine regulation of this transport pathway is crucial for normal epithelial cell functions. Among factors that control tight junction permeability are ions and their transporters. However, this area of research is still in its infancy and much more needs to be learned about. how these molecules regulate tight junction structure and functions. In this review we have attempted to compile literature on ion transporters and channels involved in the regulation of tight junctions. (C) 2007 Elsevier B.V. All rights reserved.
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