期刊
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
卷 65, 期 1, 页码 106-+出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MMBR.65.1.106-118.2001
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资金
- NCI NIH HHS [R01 CA077248, R01 CA066736, CA 77248, CA 66736] Funding Source: Medline
Polyketide natural products show great promise as medicinal agents. Typically the products of microbial secondary biosynthesis, polyketides are synthesized by an evolutionarily related but architecturally diverse family of multifunctional enzymes called polyketide synthases. A principal limitation for fundamental biochemical studies of these modular megasynthases, as well as for their applications in biotechnology, is the challenge associated with manipulating the natural microorganism that produces a polyketide of interest. To ameliorate this limitation, over the past decade several generically amenable microbes have been developed as heterologous hosts for polyketide biosynthesis. Here we review the state of the art as well as the difficulties associated with heterologous polyketide production. In particular we focus on two model hosts, Streptomyces coelicolor and Escherichia coli. Future directions for this relatively new but growing technological opportunity are also discussed.
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