期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1837, 期 4, 页码 418-426出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbabio.2013.10.004
关键词
Oxidative phosphorylation; Mitochondria; Supercomplex; ATP synthase; Electron microscopy
资金
- Netherlands Organization of Scientific Research (NWO)
Oxidative phosphoiylation (OXPHOS) is the main source of energy in eukaryotic cells. This process is performed by means of electron flow between four enzymes, of which three are proton pumps, in the inner mitochondrial membrane. The energy accumulated in the proton gradient over the inner membrane is utilized for ATP synthesis by a fifth OXPHOS complex, ATP synthase. Four of the OXPHOS protein complexes associate into stable entities called respiratory supercomplexes. This review summarises the current view on the arrangement of the electron transport chain in mitochondrial cristae. The functional role of the supramolecular organisation of the OXPHOS system and the factors that stabilise such organisation are highlighted. This article is part of a Special Issue entitled: Dynamic and ultrastructure of bioenergetic membranes and their components. (C) 2013 Elsevier B.V. All rights reserved.
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