期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 235, 期 1, 页码 70-79出版社
ACADEMIC PRESS INC
DOI: 10.1006/jcis.2000.7355
关键词
graft polymerization; protein adsorption; ceramic; polymer brush
The potential effectiveness of poly(vinyl pyrrolidone) (PVP) as a zirconia surface modifier for protein adsorption reduction was investigated using lysozyme (LYS). The relatively small size of LYS (45 x 30 x 30 Angstrom) allowed for testing the adequacy of the graft polymerization method for producing a dense surface chain coverage to exclude LYS from direct interaction with the zirconia surface. The study demonstrated that a PVP brush layer is capable of reducing lysozyme adsorption. Overall, the maximum adsorption capacity decreased (by up to about 76%) due to surface modification with increasing polymer/silane surface coverage ratio (mol/mol). Adsorption reduction, due to protein exclusion from the surface by the tethered polymer layer, increased significantly when the distance between surface chains was less than the large axis of LYS (i.e., 45 Angstrom). The present results are encouraging and suggest further consideration of polymer-modified ceramic surfaces for reducing fouling of ceramic membranes during protein ultrafiltration and producing ceramic biocompatible surfaces for biomedical applications, (C) 2001 Academic Press.
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