期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1827, 期 3, 页码 401-410出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbabio.2012.11.014
关键词
GPD2 gene; Mitochondrial glycerol-3-phosphate dehydrogenase Glycerophosphate shuttle; ROS production; Pathophysiology
资金
- Grant Agency of the Czech Republic [P303/10/P227]
- Ministry of Education, Youth and Sports of the Czech Republic [ERC CZ LL1204, RVO 67985823]
Mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) is not included in the traditional textbook schemes of the respiratory chain, reflecting the fact that it is a non-standard, tissue-specific component of mammalian mitochondria. But despite its very simple structure, mGPDH is a very important enzyme of intermediary metabolism and as a component of glycerophosphate shuttle it functions at the crossroads of glycolysis, oxidative phosphorylation and fatty acid metabolism. In this review we summarize the present knowledge on the structure and regulation of mGPDH and discuss its metabolic functions, reactive oxygen species production and tissue and organ specific roles in mammalian mitochondria at physiological and pathological conditions. (C) 2012 Published by Elsevier B.V.
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