期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1817, 期 9, 页码 1588-1596出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbabio.2012.04.015
关键词
Complex II; Nanodisc; Cardiolipin; ROS
资金
- National Science Foundation [MCB-1024908]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1024908] Funding Source: National Science Foundation
Respiratory Complex II of the mitochondrial inner membrane serves as a link between the tricarboxylic acid cycle and the electron transport chain. Complex II dysfunction has been implicated in a wide range of heritable mitochondrial diseases, including cancer, by a mechanism that likely involves the production of reactive oxygen species (ROS). Using Complex II enzymes reconstituted into nanoscale lipid bilayers (nanodiscs) with varying lipid composition, we demonstrate for the first time that the phospholipid environment, specifically the presence of cardiolipin, is critical for the assembly and enzymatic activity of the complex, as well as in the curtailment of ROS production. (C) 2012 Elsevier B.V. All rights reserved,
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