期刊
AMERICAN JOURNAL OF OPHTHALMOLOGY
卷 131, 期 3, 页码 351-354出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0002-9394(00)00830-8
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PURPOSE: To understand better the natural history of ocular toxoplasmosis by reexamining a well characterized population in Southern Brazil, METHODS: Ophthalmological examination and serologic tests for Toxoplasma gondii infection were performed in 1997 on 383 individuals who had undergone the same evaluation in 1990. RESULTS: Of 109 seronegative subjects in 1990, 21 (19.3%) became seropositive by 1997, and 2 (1.5% of previously seronegative patients; 9.5% of those known to have seroconverted) developed ocular toxoplasmosis. Seroconversion occurred more frequently in individuals under 17 years of age (16 of 46 patients, 34.8%) than in those greater than 17 years of age (5 of 63 patients, 7.9%; p = 0.002), Of 131 seropositive individuals who did not have ocular lesions in 1990, 11 (8.3%) had typical toxoplasmic lesions in 1997, Of the 13 individuals with non-specific hyperpigmented small retinal lesions in 1990, 3 (23%) presented with typical lesions in 1997. CONCLUSIONS: Acquired T. gondii infection can result in late development of ocular lesions. Small, non-specific hyperpigmented retinal lesions may represent sites of T. gondii infection in seropositive individuals, (Am J Ophthalmol 2001;131:351-354, (C) 2001 by Elsevier Science Inc. All rights reserved.).
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