期刊
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
卷 14, 期 1, 页码 211-233出版社
ELSEVIER SCI LTD
DOI: 10.1053/beha.2000.0124
关键词
acute myeloid leukaemia; multidrug resistance; MDR; MRP; LRP; P-glycoprotein; PSC 833; cyclosporin
类别
The development of refractory disease in acute myeloid leukaemia (AML) is frequently associated with the expression of one or several multidrug resistance (MDR) genes. MDRI, MRPI and LRP have been identified as important adverse prognostic factors in AML. Recently it has become possible to reverse clinical multidrug resistance by blocking P-glycoprotein-mediated drug efflux. The potential relevance of MDR and new approaches to treat refractory disease, are discussed.
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