期刊
MOLECULAR AND CELLULAR BIOLOGY
卷 21, 期 5, 页码 1866-1873出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.21.5.1866-1873.2001
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资金
- NIAMS NIH HHS [R01 AR045113, AR45113] Funding Source: Medline
We have determined that I-mfa, an inhibitor of several basic helix-loop-helix (bHLB) proteins, and XIC, a Xenopus ortholog of human I-mf domain-containing protein that shares a highly conserved cysteine-rich C-terminal domain with I-mfa, inhibit the activity and DNA binding of the HMG box transcription factor XTcf3. Ectopic expression of I-mfa or XIC in early Xenopus embryos inhibited dorsal axis specification, the expression of the Tcf3/beta -catenin-regulated genes siamois and Xnr3, and the ability of beta -catenin to activate reporter constructs driven by Lef/Tcf binding sites. I-mfa domain proteins can regulate both the Wnt signaling pathway and a subset of bHLH proteins, possibly coordinating the activities of these two critical developmental pathways.
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