Synthesis and anti-inflammatory activities of N4,N5-disubstituted-3-methyl-1H-pyrazolo[3,4-c]pyridazines

The synthesis and anti-inflammatory activity of 4,5-dihydroxy-3-methyl-1H-pyrazolo[3,4-c]pyridazine (4), 4,5-dichloro-3-methyl-1 H-pyrazolo[3,4-c]pyridazine (5), 4,-benzoyloxy-3-methyl-1-benzoyl-1H-pyrazolo[3,4-c]pyridazin-5yl benzoate (6), 3-methy-N-4,N-5-bis(4-methylphenyl)- 1H-pyrazolo[3,4-c]pyridazine-4,5-diamine (7), 4{[5-(4-carboxyanilino)-3-methyl-1H-pyrazolo[3,4-c]pyridazin-4yl}amino}benzoic acid (8), N-[5-(benzoylamino)-3-methyl- 1H-pyrazolo[3,4-c]pyridazin-4-yllbenzami (9) and 3-methyl-N-4,N-5 bis-4-(1 H-benzimidazol-2yl)phenyl]-1H-pyrazolo[3,4-c]pyridazine-4,5-diamine (10) are being reported. (C) 2001 Elsevier Science Ltd. All rights reserved.