期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1807, 期 6, 页码 735-745出版社
ELSEVIER
DOI: 10.1016/j.bbabio.2011.03.010
关键词
Mitochondrion; Oncogene; Bcl-2; Permeability transition pore; Cell death; Metabolism
资金
- le Centre National de la Recherche Scientifique (CNRS)
- l'Agence Nationale de la Recherche (ANR) [ANR-08PCVI-0008-01]
- l'Institut National pour le Cancer (INCa) [2008-1-PL BIO-04-CNS ON1]
- l'Universite Paris Sud
- Biomedical Research Council of Singapore
- National Medical Research Council of Singapore
- Singapore Cancer Syndicate
- Ministry of Education (Tier 2) Singapore
- Duke-NUS Graduate Medical School, Singapore
- Cancer Sciences Institute, NUHS, Singapore
Defective or inefficient apoptosis is an acquired hallmark of cancer cells. Thus, a thorough understanding of apoptotic signaling pathways and insights into apoptosis resistance mechanisms are imperative to unravel novel drug targets for the design of more effective and target selective therapeutic strategies. This review aims at providing an overview of the recent understanding of apoptotic signaling pathways, the main mechanisms by which cancer cells resist apoptotic insults, and discusses some recent attempts to target the mitochondrion for restoring efficient cell death signaling in cancer cells. This article is part of a Special Issue entitled: Bioenergetics of Cancer. (C) 2011 Published by Elsevier B.V.
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