期刊
JOURNAL OF NEUROCHEMISTRY
卷 76, 期 6, 页码 1628-1635出版社
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1471-4159.2001.00193.x
关键词
axonal transport; capsaicin sensitivity; carrageenan inflammation; glutamate release; primary afferent; VR1 capsaicin receptor mRNA
Capsaicin receptors are expressed in primary sensory neurons and excited by heat and protons. We examined the inflammation-induced changes of the level of VR1 capsaicin receptor mRNA in sensory neurons and the sensitivity of primary afferents to capsaicin. Carrageenan treatment induced axonal transport of VR1 mRNA, but not that of preprotachykinin mRNA, from the dorsal root ganglia to central and peripheral axon terminals. The sensitivity of central terminals to capsaicin, which was estimated by measuring the capsaicin-evoked release of glutamate from the dorsal horn, was increased by peripheral inflammation, and such an increase was suppressed by inhibiting the RNA translation in the dorsal horn with cycloheximide and an intrathecal injection of VR1 antisense oligonucleotides. Thus, peripheral inflammation induces the axonal transport of VR1 mRNA, which may be involved in the hypersensitivity of primary afferents to capsaicin and the production of inflammatory hyperalgesia.
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