期刊
EUROPEAN RESPIRATORY JOURNAL
卷 17, 期 3, 页码 416-421出版社
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09031936.01.17304160
关键词
acoustic rhinometry; airway inflammation; exhaled nitric oxide; dust and gas exposure
Exposure to gases and dust may induce airway inflammation. It was hypothesized that heavy construction workers who had been exposed to dust and gases in underground construction work for 1 yr, would have early signs of upper and lower airway inflammation, as compared to outdoor workers. A study group comprising 29 nonsmoking underground concrete workers (mean I so age 44 +/- 12 yrs), and a reference group of 26 outdoor concrete workers (39 +/- 12 yrs) were examined by acoustic rhinometry, nasal and exhaled nitric oxide spirometry and a questionnaire on respiratory symptoms. Exposure measurements mere carried out. The underground workers had higher exposure to total and respirable dust, a-quartz and nitrogen dioxide than the references (p < 0.001). The occurrence of respiratory symptoms was higher in the underground workers than in the references (p < 0.05). exhaled nitric oxide Exhaled nitric oxide (NO) (geometric mean +/- SEM) was higher in the underground workers than in the references (8.4 +/- 1.09 versus 5.6 +/- 1.07 parts per billion (ppb), p = 0.001), whereas spirometric values mere comparable. The underground workers had smaller nasal cross-sectional area and volume than the references, and more pronounced increases after decongestion (p < 0.001). To conclude the exposure in underground construction may cause nasal mucosal swelling and increased levels of exhaled nitric oxide, indicating signs of upper and lower airway inflammation.
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