Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554

A novel compound nafuredin, was isolated as an inhibitor of anaerobic electron transport (NADH-fumarate reductase). It was obtained from culture broth of Aspergillus niger FT-0554 isolated from a marine sponge, The structure was elucidated as an epoxy-delta -lactone with an attached methylated olefinic side chain on the basis of spectral analysis.